What more can be said about Tina Fey ('30 Rock') that hasn't been said already? In her breakout year in which La Fey claimed box office gold ('Baby Mama') and a popularity contest (cue those Sarah Palin skits), it all comes back to her adorable Liz Lemon that delivers the icing on the comedy cake. Everything from eating an entire sandwich in one take(!) to those deadpan reactions to Alec Baldwin, Fey seems like she has just shown an appetizer of what she can do on screen.
Other Nominees: Christina Applegate ('Samantha Who?'), Felicity Huffmann ('Desperate Housewives'), Ashley Jensen ('Ugly Betty)', Mary Louise Parker ('Weeds')